Fitoterapia. The structure was established on the basis of chemical and spectral data. In our present work on the phytochemical and pharmacological properties of the leaves of vitex negundo was evidently support the long term Anti oxidant property, anti inflammatory, anti cancer and anti inflammatory activity of Vitex negundo. Roy SK, Bairwa K, Grover J, Srivastava A, Jachak SM. Vitex negundo and its medicinal value. The phytochemical constituents of medicinal plants often function indi-vidually, additively or synergistically in improvement of health [31]. It is used externally in the form of paste or oi and orally in the form of powder, leaf juice or water decoction.It treats diseases caused due to vitation of Vata and Kapha, Headache, Skin affections, Wounds, Swelling, Asthmatic Pains, male and female Sexual ailments and Reproductive problems. Zheng CJ, Li HQ, Ren SC, Xu CL, Rahman K, Qin LP, Sun YH. 2009 Jun;16(6-7):560-7 -, Chem Pharm Bull (Tokyo). Fitoterapia. Life Cycle: Perennial Woody Recommended Propagation Strategy: Seed Country Or Region Of Origin: Asia, Africa Wildlife Value: Attracts butterflies. The ethanolic extract of leaves has been found safe as LD 50 dose (by oral route) of it was recorded in non-toxic dose range. This is the first review presenting up-to-date information about the VN, its bioactive constituents and their mode of action. -, BMC Complement Altern Med. Vitex negundo (or nirgundi or nochi) is one of the herbs mentioned in the Ayurveda and it grows in the waste lands or commonly cultivated as a hedge plant. Marine macroalga Caulerpa: role of its metabolites in modulating cancer signaling. Vitex negundo (VN), commonly known as “chaste tree”, is an ethnobotanically important plant with enormous medicinal properties. These bioactive compounds exhibit anti-inflammatory, antioxidant, antidiabetic, anticancer, antimicrobial. However, little is known about the role of the circRNA-miRNA axis in PCOS progression. These bioactive compounds exhibit anti-inflammatory, antioxidant, antidiabetic, anticancer, antimicrobial. INTRODUCTION Vitex negundo is well known for its medicinal value [1]. Also, there are ten types of EphAs (EphA1-10) and six types of EphBs (EphB1-6). 2015 May;29(5):633-47. doi: 10.1002/ptr.5303. PMID: 32595989 [PubMed], Cancers, Vol. medicinal plant for the preparation of various valuable medicines has caused drastic reduction of this important genetic resource in India. Universal Journal of Pharmacy, 2, 42-46. Vitex negundo (nirgundi, in Sanskrit and Hindi) is a deciduous shrub naturalized in many parts of the world. Vitex negundo Linn. 4.11.3.4.1 Pentacyclic triterpenes. The conventional method for propagation of V. negundo is through seeds or root suckers. Different species of Vitex vary in chemical composition, thus producing different phytochemicals. 2013 Oct;24(9):928-36 Epub 2019 Apr 12. The role of unopposed estrogen in the development of endometrial cancer has been investigated in numerous studies. leaves of Vitex negundo L. was subjected to pharmacological analysis and was explored for possible anti-bacterial activity against Salmonella typhiand Pseudomonmas aeruginosaby agar diffusion method. Apoptosis; Cancer; Reactive oxygen species; Signaling; Vitex negundo. Raji, R. (2013) Biological Activities, Chemical Constituents and Medicinal Value of Vitex negundo Linn. Vitex negundo, a medicinal plant of the family ‘Verbenaceae’ and commonly known as chaste tree or five-leaved chaste tree or horseshoe vitex. Advanced search can include the following: Vitex negundo and its medicinal value. After having analyzed the various chemical components available in different parts of Vitex negundo, it is essential that focus shifts to the medicinal applica- Crossref Zheng CJ, Zhang XW, Han T, Jiang YP, Tang JY, Brömme D, Qin LP. This plant has been extensively investigated by many scientists for its medicinal activities. Different species of Vitex vary in chem …. Vitex negundo (VN), commonly known as “chaste tree”, is an ethnobotanically important plant with enormous medicinal properties. VN, reportedly, perturbs many cancer-signaling pathways involving p-p38, p-ERK1/2, and p-JNK in LPS-elicited cells, N-terminal kinase (JNK), COX-1 pathways, MAPK, NF-κB, tumor necrosis factor α (TNF-α), Akt, mTOR, vascular endothelial growth factor, hypoxia-inducible factor (HIF-1α). AbstractWhile childbearing protects against risk of epithelial ovarian cancer (EOC), few studies have explored the impact on maternal EOC risk of sex of offspring, which may affect the maternal environment during pregnancy. The objective of this review is to summarize our knowledge about the contribution of vitamin D3 to physiological and pathological processes within the ovary.  |  Vitex Species: negundo Family: Lamiaceae Uses (Ethnobotany): Various medicinal uses of various parts of the plant. V. negundo and V. agnus castus are reported to contain the iridoid glucosides aucubin and agnuside [1]. Several bioactive compounds obtained from VN have been commercialized and others are under investigation. Phytochemical and Pharmacological Profile of Vitex negundo. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Vitex arborea Desf. In young women, repeated harvest of few oocytes in well-stimulated ART cycles is a likely predictor of advanced menopausal age and may thus serve as an... Ephrin and Eph Receptor Signaling in Female Reproductive Physiology and Pathology. Natural products are rich in several potent bioactive compounds, targeting complex network of proteins involved in various diseases. Balkrishna A, Sakat SS, Karumuri S, Singh H, Tomer M, Kumar A, Sharma N, Nain P, Haldar S, Varshney A. 2020 Oct 30;11:566490. doi: 10.3389/fphar.2020.566490. However, poor seed germination potential and the dependence of a root sucker on plant age restrict its is a large aromatic shrub distributed throughout India. Journal of Assisted Reproduction and Genetics. Abstract Please enable it to take advantage of the complete set of features! Epub 2018 Mar 6. Balraj Singh Gill, Richa Mehra, undefined Navgeet, Sanjeev Kumar, Vitex negundo and its medicinal value, Molecular Biology Reports, 10.1007/s11033-018-4421-3, (2018). USA.gov. Almost all the sections of the plant possess a massive amount of phytochemical secondary metabolites that impart an unparalleled variety of medicinal uses of the plant. The Vitex negundo linn is another Indian plant, which have enormous traditional uses against various diseases. Herbal Decoction Divya-Peedantak-Kwath Alleviates Allodynia and Hyperalgesia in Mice Model of Chemotherapy-Induced Peripheral Neuropathy via Modulation in Cytokine Response. Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders among reproductive-age women. Roots, fruits, flowers, leaves and bark of Vitex negundo have great medicinal value and are used for medicinal and insect repellent purposes1-10. Vitex negundo (VN), commonly known as "chaste tree", is an ethnobotanically important plant with enormous medicinal properties. Balraj Singh Gill, Richa Mehra, undefined Navgeet, Sanjeev Kumar, Vitex negundo and its medicinal value, Molecular Biology Reports, 10.1007/s11033-018-4421-3, (2018). This plant has been used for hundred of years in India and in the Philippines, where the health department endorsed its use as an herbal medicine.. Vitex negundo can be used to repel house flies. COVID-19 is an emerging, rapidly evolving situation. Effect of Timing of Gonadotropin-Releasing Hormone Agonist Administration for Ovarian Protection in Patients with Breast Cancer. AbstractSTUDY QUESTIONDo young women with early ovarian ageing (EOA), defined as unexplained, and repeatedly few oocytes harvested in ART have an increased risk of age-related events?SUMMARY ANSWERAt follow-up, women with idiopathic EOA had an increased risk of age-related events compared to women with normal ovarian ageing (NOA).WHAT IS KNOWN ALREADYEarly and premature menopause is associated with an increased risk of cardiovascular diseases (CVDs), osteoporosis and death. Most of the published data... circPUM1 promotes polycystic ovary syndrome progression by sponging to miR-760. Natural products are rich in several potent bioactive compounds, targeting complex network of proteins involved in various diseases. heterophylla. Vitex (Vitex agnus-castus) is a plant used in herbal medicine. Several bioactive compounds have been extracted from leaves, seeds, roots in form of volatile oils, flavonoids, lignans, iridoids, terpenes, and steroids. Abstract Endometrial cancer is the most common gynecologic cancer and is predominantly endocrine-related. Previous work on this plant reveals the presence of a variety of compounds from the leaves [1-11]. Clarification of their roles in the female reproductive system is crucial to understanding the physiology and pathology of this syste... Adu-Gyamfi EA, Czika A, Liu TH, Gorleku PN, Fondjo LA, Djankpa FT, Ding YB, Wang YX. It has been ascertained that PDCD4 causes glucose and lipid metabolism disorders, insulin resistance, oxidative stress, chronic inflammatory response, and gut flora disorders to regulate the progression ... Lu K, Chen Q, Li M, He L, Riaz F, Zhang T, Li D, Assessing and validating housekeeping genes in normal, cancerous, and polycystic human ovaries. Vitex negundoLinn.is credited with innumerable medicinal activities like analgesic, anti-inflammatory, anticonvulsant, antioxidant, bronchial relaxant, hepatoprotective, etc. Labdanes and megastigmanes from Vitex negundo var. This may be mild, moderate or even severe. Mol Biol Rep. 2019 Jun;46(3):3545-3555. doi: 10.1007/s11033-019-04743-5. 2013 Dec 04;13:343 Biologically synthesized green silver nano-particles from leaf extract of Vitex negundo L. induce growth-inhibitory effect on human colon cancer cell line HCT15 136. Ephrins are ligands of Eph receptors (Ephs); both of which are sorted into two classes, A and B. Anti-inflammatory and anti-osteoporotic lignans from Vitex negundo seeds. Commonly known in the Ilocos region as dangla, lagundi has been clinically tested to be effective in the treatment of colds, flu, bronchial asthma, chronic bronchitis, and pharyngitis. Effect of solvent residues of Vitex negundo L. and Cassia fistula L. leaves (0.5 and 1%) was studied on egg laying and adult emergence of Callosobruchus maculatus Fab. Programmed cell death factor 4 (PDCD4) is originally described as a tumor suppressor gene that exerts antineoplastic effects by promoting apoptosis and inhibiting tumor cell proliferation, invasion, and metastasis. Mol Biol Rep. 2018 Oct 11;: Authors: Gill BS, Mehra R, Navgeet, Kumar S Abstract Natural products are rich in several potent bioactive compounds, targeting complex network of proteins involved in various diseases. Epub 2019 Jul 11. Vitex agnus-castus negundoides Kuntze. Secondly, The CCK-8 and apoptosis experiment results suggested that downregulated miR-... Vitamin D3 action within the ovary - an updated review. Natural products are rich in several potent bioactive compounds, targeting complex network of proteins involved in various diseases. ConclusionsThis study confirms recent investigations demonstrating that conventional HKGs, such as GAPDH and beta-actin, are not suitable reference genes for specific pathological conditions, emphasizing the importance of determining the best HKGs on a case-by-case basis and according to tissue type. Different reproductive factors such as younger age at menarche, late age at menopause, infertility, nulliparity, age of birth of the first child, and long-term use of unopposed estrogens during hormone replacement therapy have been associated with an increased risk of endometrial cancer. Early ovarian ageing: is a low number of oocytes harvested in young women associated with an earlier and increased risk of age-related diseases? Vitex cannabifolia Siebold & Zucc. The review includes 161 references on the genus Vitex, and comprises ethnopharmacology, morphology and microscopy, phytoconstituents, pharmacological reports, clinical studies, and toxicology of the prominent species of Vitex. Programmed cell death factor 4 (PDCD4), a novel therapy target for metabolic diseases besides cancer. Different species of Vitex vary in chemical composition, thus producing different phytochemicals. ann It has been used since ... medicinal properties have been ascribed to Vitex negundo Linn. Vitex negundo (VN), commonly known as "chaste tree", is an ethnobotanically important plant with enormous medicinal properties. AbstractAnti-M üllerian Hormone (AMH) is critical for physiologic involution of the Mullerian ducts during sexual differentiation in the male fetus. It is cultivated as a hedge and medicinal plant, and is also sometimes grown as an ornamental[303. It also produces pain relief similar to aspirin and morphine in animal tests. Would you like email updates of new search results? VN is typically known for its role in the modulation of cellular events like apoptosis, cell cycle, motility of sperms, polycystic ovary disease, and menstrual cycle. It has antiseptic, astringent, anti-inflammatory and antipyretic properties. Firstly, we found that miR-760 expression was decreased in PCOS tissues insulin treated GCs, KGN and SVOG cells. is a woody plant found mainly in Indian subcontinent and its neighbouring countries. Trees and Herbs (with medicinal value) To treat disease and by using (Herbs)/herbal medicine. More than hundred patents were found on its medicinal applications as a rheumatoid arthritis 137 and for skin care 138 etc. Crossref Front Pharmacol. The circRNA-miRNA axis functions in various diseases progression have been partially revealed in the past two decades. Some consider it to have originated in India and the Philippines. There are five types of ephrin-As (ephrin-A1-5) and three types of ephrin-Bs (ephrin-B1-3). Vitex negundo is indicated in Joint Disorder, Low Back Pain, Osteoarthritis, Rheumatoid Arthritis (Amavata), Sciatica, Spondylosis, and Vata Vyadhi. Xu JM, Hu BC, Yuan L, Wu YL, Luan SS, Yuan T, Wang D, Chen LX. Pain is a feeling which may be sharp or dull, something that is unpleasant to mind and body. Lagundi in Traditional and Folkloric Medicine Lagundi or Vitex negundo has been traditionally used as herbal medicine by Philippine and Indian folks. NIH Falko P. Drijfhout, E. David Morgan, in Comprehensive Natural Products II, 2010. Natural products are rich in several potent bioactive compounds, targeting complex network of proteins involved in various diseases. Kashyapiyakrishisukti recommends . NCI CPTC Antibody Characterization Program, Phytomedicine. Conclusion: There was no difference in the ovarian protective effect according to the difference in the timing of administration of GnRHa. Mol Biol Rep. 2018 Oct 11;: 2004 Nov;52(11):1269-72 Properties of Vitex negundo as a medicinal plant include antihistamine, antioxidant, and anticonvulsant uses. Several bioactive compounds have been extracted from leaves, seeds, roots in form of volatile oils, flavonoids, lignans, iridoids, terpenes, and steroids. 2014 Mar;93:31-8. doi: 10.1016/j.fitote.2013.12.006. Vitex Negundo is a medicinal herb. 2019 Sep;137:104265. doi: 10.1016/j.fitote.2019.104265. Tuesday, 12 January 2010. Vitex supplements typically contain extracts of the fruit and/or seed of the plant. In contrast, there is a growing body of evidence for a protective role of oral contraceptives. Also known as chaste tree or chasteberry, it's often taken as a remedy for women's health problems. VN, reportedly, perturbs many cancer-signaling pathways involving p-p38, p-ERK1/2, and p-JNK in LPS-elicited cells, N-terminal kinase (JNK), COX-1 pathways, MAPK, NF-κB, tumor necrosis factor α (TNF-α), Akt, mTOR, vascular endothelial growth factor, hypoxia-inducible factor (HIF-1α). The Journal of Obstetrics and Gynecology of India. Phytother Res. Herbal medicine, rather than merely curing a particular disease, aims at returning the body back to its natural state of health. Authors: Gill BS, Mehra R, Navgeet, Kumar S It is a feeling that is triggered in nervous system. 12, Pages 1766: Endocrine Risk Factors of Endometrial Cancer: Polycystic Ovary Syndrome, Oral Contraceptives, Infertility, Tamoxifen. It is a muscle relaxant and pain relieving herb.  |  National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. ... medicinal value and mention its use in religious rites, while the Vamana Purana considers it to be a holy plant (Sensarma, 1998). PMID: 32469224 [PubMed - as supplied by publisher], https://www.ncbi.nlm.nih.gov/pubmed/30311123?dopt=Abstract. It is widely used in folk medicine, particularly in South and Southeast Asia. Vitex negundo, commonly known as the Chinese chaste tree, five-leaved chaste tree, or horseshoe vitex, or nisinda is a large aromatic shrub with quadrangular, densely whitish, tomentose branchlets. It is especially useful in rheumatism, rheumatic swellings of the joints and in sprains. It was observed that methanolic extract of Vitex negundo showed equal activity against both the bacteria with MIC value equal to 5mg/mL. Lagundi is generally used for the treatment of coughs, asthma symptoms, and other respiratory problems. It;'s main health benefit is to ease respiratory complaints. Abstract -. Clipboard, Search History, and several other advanced features are temporarily unavailable. Analysis of flavonoids and iridoids in Vitex negundo by HPLC-PDA and method validation. Vitex negundo Linn. Nirgundi Oil (Vitex negundo) - Benefits, Uses and Properties. HHS This is the first review presenting up-to-date information about the VN, its bioactive constituents and their mode of action. In women, AMH is a product of the small antral follicles in the ovaries and serves to function as an autocrine and paracrine regulator of follicular maturation. Offspring sex and risk of epithelial ovarian cancer: a multinational pooled analysis of 12 case –control studies. Vitex negundo (VN), commonly known as "chaste tree", is an ethnobotanically important plant with enormous medicinal properties.  |  Different species of Vitex vary in chemical composition, thus producing different phytochemicals. Epub 2013 Dec 22. eCollection 2020. and on percentage of larval parasitism by Dinarmus vagabundus (Timberlake). Lagundi (scientific name: Vitex negundo) is a shrub that grows in the Philippines. Lagundi (Vitex negundo) Lagundi (scientific name: Vitex negundo) is a shrub that grows in the Philippines. Binding of ephrins to the Eph receptors activates signaling cascades that regulate several biological processes such as cellular proliferation, differentiation, migration, angiogenesis and vascular remodeling. Natural products are rich in several potent bioactive compounds, targeting complex network of proteins involved in various diseases. It is one of the ten herbal medicines endorsed by the Philippine Department of Health as an effective herbal medicine with proven therapeutic value. Vitex negundo and its medicinal value Author: Gill, Balraj Singh, Mehra, Richa, Navgeet,, Kumar, Sanjeev ... Vitex negundo (VN), commonly known as “chaste tree”, is an ethnobotanically important plant with enormous medicinal properties. -, Chem Biol Interact. -, Anticancer Drugs. NLM Several investigations have probed the aberrant expression of PDCD4 with the progression of metabolic diseases, such as polycystic ovary syndrome (PCOS), obesity, diabetes, and atherosclerosis. Several bioactive compounds obtained from VN have been commercialized and others are under investigation. We performed a pooled analysis among parous participants from 12 case –controls studies comprising 6872 EOC patients and 9101 controls. Abstract back to its natural state of health [30]. MicroRNA miR-760, which is characterized by tissue-specific, has been studied in several cancers. 2018 May;16(3):147-152. doi: 10.1016/j.joim.2018.03.001. Vitex negundo (VN), commonly known as "chaste tree", is an ethnobotanically important plant with enormous medicinal properties. Cowpea seeds … Different species of Vitex vary in chemical composition, thus producing different phytochemicals. Epub 2015 Jan 30. Different species of Vitex vary in chemical composition, thus producing different phytochemicals. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using multivariable logistic regression for case–control associations and polytomous logistic regression for histotype-specific associations, all adjusted for po tential confounders. Play Value: This site needs JavaScript to work properly. VN is typically known for its role in the modulation of cellular events like apoptosis, cell cycle, motility of sperms, polycystic ovary disease, and menstrual cycle. Different species of Vitex vary in chemical composition, thus producing different phytochemicals. Vitex agnus-castus negundo (L.) Kuntze. Keywords: Casticin from Vitex species: a short review on its anticancer and anti-inflammatory properties. V. negundois a small tree about 2-8 m in height with quadrangular branches. Vitex negundo and its medicinal value. Our results have identified reliable HKGs for studies of normal human ovaries and those affected by OEA, OMA, OSPC, or PCOS, as well as combined studies of control subjects vs. each cancer or PCOS group. J Integr Med. Vitex negundo 161800 ± 36 143400 ± 23 5330 ± 16 200 ± 9 280 ± 10 120 ± 5 Potassium was higher in both plants but contained Adhatoda vasica 31190 ± 20.3 68070 ± 35 705 ± 8 64 ± 5 67 ± 6 41 ± 3 less Na. 2015 Jan 5;225:32-9 The word pain comes from the Latin name - Poena, means a fine or penalty. Properties of Vitex negundo by HPLC-PDA and method validation, Grover J Srivastava... Found that miR-760 expression was decreased in PCOS progression ephrin-A1-5 ) and six types of EphAs ( EphA1-10 and... By publisher ], https: //www.ncbi.nlm.nih.gov/pubmed/30311123? dopt=Abstract name - Poena, means a fine or penalty relieving. Publisher ], https: //www.ncbi.nlm.nih.gov/pubmed/30311123? dopt=Abstract women 's health problems search... 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For its medicinal value of Vitex negundo ( VN ), commonly known as `` chaste tree '' is! In Vitex negundo ) is critical for physiologic involution of the published data... promotes... Antihistamine, antioxidant, antidiabetic, anticancer Drugs Bairwa K, Qin LP, Sun YH in Response. Method for Propagation of v. negundo is through seeds or root suckers Hu BC, Yuan T, Jiang,! And Hyperalgesia in Mice Model of Chemotherapy-Induced Peripheral Neuropathy via Modulation in Cytokine Response: [.